ScienceAugust 2026 · p. 6
Exploring the potential entourage effect
For quite some time, discussions surrounding the potency of psychedelic mushrooms have centered primarily on one compound: psilocybin. As the best-known psychoactive constituent of these mushrooms, psilocybin has understandably become the focus of modern clinical research and therapeutic development. But a mushroom is far more chemically complex than a single molecule. Psilocybin producing fungi contain a diverse mixture of structurally related tryptamine alkaloids, many of which remain poorly understood. This raises a question that I believe deserves far more attention: could the overall psychedelic experience be influenced not only by psilocybin and psilocin, but by the interaction of the mushroom's entire alkaloid profile? This idea is often described as the entourage effect.
GeneticsAugust 2026 · p. 2
GeneticsAugust 2026 · p. 4
CultureAugust 2026 · p. 9
San Pedro, Huachuma and the Sonoran collection
Mescaline. Some people have heard of it and fewer have experienced it. Those who know typically associate it with the Peyote cactus, native to Mexico and very small portions of Texas. There is an entirely different group of mescaline containing cacti that has been used ceremonially by the indigenous groups of Peru, Bolivia and Ecuador for thousands of years. It is known as San Pedro, or as the Andean shamans call it, Huachuma.
GeneticsAugust 2026 · p. 15
Field NotesAugust 2026 · p. 18
The search for Psilocybe neoxalapensis
I specialize in fungi in cloud rainforests: forests at an altitude of 1200m to 2500m above sea level that receive more than 2000mm of rainfall per year. These forests are full of valleys full of fog and mist, and those areas specifically are my specialty. In 2017 I made my first trip to Mexico, to the states of Oaxaca and Veracruz, looking for species with a characteristic known as a pseudorhiza.
ScienceAugust 2026 · p. 28
Fungi are certainly not static organisms; while we may see them as part of the soil or the decaying logs on which they subsist, this view is a biological illusion. Most of the lifecycle of any given fungus is all but invisible. In their ineffable silence, Funga represent one of the most mobile groups of organisms on Earth. From microscopic spores drifting in the air around us to the slow, relentless expansion of underground mycelial networks, fungi have evolved a suite of dispersal mechanisms that allow them to colonize every corner of the globe.
OpinionAugust 2026 · p. 35
A $127 billion threat
Why waiting for further clinical trials might cost us the future. A late-2025 study published in Pharmacological Research reported that chronic, low-dose psilocybin microdosing normalized liver fat, reversed insulin resistance and halted weight gain in diet-induced obese mice. Notably, this effect was caused by psilocybin's interaction with 5-HT2B receptors in the liver and body, rather than the 5-HT2A receptor in the brain.
CactusAugust 2026 · p. 39
GeneticsAugust 2026 · p. 42
Gifted by Q, What The Fungi
BusinessJune 2026 · p. 8
Every Thursday at 3 pm Eastern Time, mushroom entrepreneurs from around the world gather online at the Mycopreneur Incubator to level up together. Mushroom entrepreneurship comes in many shapes and sizes: spore vendors, legacy market operators, state-licensed psilocybin facilitators in Oregon and Colorado, functional mushroom brand owners, testing lab scientists, mycomaterials designers, event organizers and journalists. When I first started Mycopreneur in 2020, the guiding vision was always about connecting mushroom entrepreneurs to each other and providing resources and opportunities for collaboration and mutual success.
GeneticsJune 2026 · p. 11
GeneticsJune 2026 · p. 15
Twamak is a Fungus Frequency original that comes from a cross of Tidalwave and AMAK. From the very first generation this creation has been extremely aggressive. This culture produces dense albino fruits with gills that turn beautifully blue at maturation.
OpinionJune 2026 · p. 20
In the past few years, the psilocybin mushroom community has experienced rapid growth. What was once a relatively quiet, underground network of cultivators, researchers and enthusiasts has expanded into a global conversation spanning education, harm reduction, microscopy and personal exploration. With that growth, however, has come a new set of challenges. At its core, this community is built on curiosity, healing and a shared respect for these organisms. But like any rapidly expanding ecosystem, imbalance can emerge.
GeneticsJune 2026 · p. 22
GeneticsJune 2026 · p. 26
CultivationJune 2026 · p. 30
Tall, elegant and ghostly pale under cultivation lights, Panaeolus cyanescens has become one of the most respected species in the world of advanced mushroom cultivation. Known among enthusiasts simply as Pans, these delicate tropical mushrooms are prized for their rapid growth, demanding environmental needs and striking visual appearance. Growing Pans successfully requires precision: nutrient-rich substrates, balanced moisture levels, warm temperatures and significantly more fresh air than many beginner-friendly species.
ScienceJune 2026 · p. 35
After decades of stigma, prohibition and regulatory resistance, psychedelic medicine is rapidly moving into the mainstream of modern healthcare. In 2026, momentum surrounding compounds such as psilocybin, MDMA, ibogaine and 5-MeO-DMT has accelerated at both the federal and state level. While federal legalization has not occurred, the shift in tone from Washington represents one of the most significant policy changes since psychedelics were classified as Schedule I substances in the 1970s.
GeneticsFebruary 2026 · p. 2
GeneticsFebruary 2026 · p. 9
ArtFebruary 2026 · p. 13
I work in clay because clay does not allow shortcuts. Every stage of the process is visible. The armature. The rough block in. The imbalance before refinement. Clay forces honesty, because nothing can be rushed or hidden. That transparency mirrors how cultivation should be taught. Slowly. Clearly. With responsibility at every step. My work lives at the intersection of art, cultivation and harm reduction. The clay figures I create are not mascots or satire for shock value. They are witnesses.
GeneticsFebruary 2026 · p. 17
Shakti x Blue-nips
ScienceFebruary 2026 · p. 23
Psilocybe subtropicalis is a small, elusive psilocybin-producing mushroom native to southern Mexico, most commonly encountered in the highlands stretching from Xalapa to Oaxaca. Often overlooked due to its modest size, this species carries a deep cultural and scientific legacy rooted in place, climate and time. Originally described in 1958 as Psilocybe semperviva, meaning forever living, this species moved through several classifications before Gastón Guzmán established the name Psilocybe subtropicalis in the mid-1990s.
OpinionFebruary 2026 · p. 25
Oregon opened its doors to legal psilocybin treatment centers in 2022. Since then over 25% of the treatment centers that opened have shut down. Why could this be the case? One of the major factors is pricing. People will spend thousands of dollars for a single guided journey and a bit of therapy. The barrier to entry for a guided experience is very unaffordable for the general population.
GeneticsFebruary 2026 · p. 27
GeneticsJanuary 2026 · p. 2
The lineage that whispered back
Paja Crown is a uniquely crafted variety with roots stretching across continents. Bred by Evyatar Siani in Israel, it is a cross between the well-known Ghost lineage and the lesser-known landrace Paja Poke, which traces its origins to Brazil. Like many extraordinary lineages, Paja Crown's story could have easily been lost to time. Only a few cultivators know that this mushroom almost slipped through the cracks and might have been lost entirely if not for the preservation work we undertook.
GeneticsJanuary 2026 · p. 10
El Dragōn comes from a cross of an El Choco monokaryon and a dikaryon of Ghidorah. The initial fruiting produced fruits similar to Ghidorah, only more tame. Then an albino pin popped up on agar, and both lines produced gnarly albino fruits with curled caps and very dark spots in the middle of the caps.
GeneticsJanuary 2026 · p. 17
I moved to Colorado from New Jersey in 2023, specifically because of the benefits of Prop 122. Bloberry was my very first grow in my new lab and it started out as an unlabeled LC syringe. I was told that it was SNAPE. What I ended up with in the first flush was a mutation, what I called Bloberry. I knew it was special because of how blue it turned when it was oxidized.
ScienceJanuary 2026 · p. 24
Veterans seek healing beyond conventional medicine
Post-traumatic stress disorder remains one of the most challenging conditions faced by U.S. veterans. Conventional treatments often reduce symptoms but fail to bring full emotional healing. Many veterans report feeling detached or numb while on standard medications, leading researchers to explore more transformative approaches. Because the Department of Veterans Affairs has yet to authorize psychedelic treatment, many veterans must travel abroad or join private studies to access this care.
ScienceJanuary 2026 · p. 26
What the latest psilocybin research reveals
In recent months, psilocybin has once again captured global scientific attention. From groundbreaking aging studies to long-term mental health benefits, the past few months have yielded compelling evidence that psilocybin's potential reaches far beyond its countercultural history. Not all findings are encouraging. Researchers stress that therapeutic use must remain within strict clinical settings under professional supervision.
CultureJanuary 2026 · p. 31
Most people in the mushroom community are familiar with Terence McKenna's famed Stoned Ape Theory, but what if the vitalizing and elevating potential of psilocybin mushrooms extends to other animal species that call this planet home? On a recent trip to the Bwindi Impenetrable Forest of Uganda, I learned that the critically endangered mountain gorillas that live in the park intentionally seek out various wild mushrooms during the rainy season.
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